Save Incubator Space with CELLdisc

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The aim of mass cell culture is to produce large quantities of cells mostly used for industrial or clinical applications. Users can choose from a variety of different disposables and concepts. To reduce the cost of the scale up process to a minimum, different factors need to be considered and evaluated.

If multilayer devices such as the Greiner Bio-One CELLdisc are to be used, not only growth area and the number of cells
per device should be taken into account but also how effectively incubator space is utilised by them.
The innovative CELLdisc with its round and ergonomic design stands out from existing rectangular devices. The
cuboid nature of these alternatives would, at first glance, imply an optimal use of space within an incubator that is itself
cuboid in design. However, in reality, the length and width of such systems do not correspond ideally to the dimensions
of standard incubators and leave a lot of space unused. Additionally such devices cannot be positioned next to each
other as this could compromise consistent thermal distribution, because when units touch each other so access to the
temperature environment of the incubator is compromised.
CELLdisc however, thanks to the cylindrical nature of the design, can be placed directly next to one another and still
receive uniform exposure to the optimum temperature of the incubator. Due to this fact and the 40% higher surface
volume/ratio CELLdisc offers over standard competitive systems, utilisation of incubator space is far more efficient
when using CELLdisc than rectangular devices. (See Table 1)

Table 1: Utilisation of incubator space - exemplary calculation of multilayer devices with comparable dimensions
 

CELLdisc 16 layers

Competitor A 10 layers, rectangular form

Competitor B 10 layers, rectangular form (high density version)

Dimensions (L x W x H incl. cap)

ø 20 cm, H 22 cm

33 cm x 20 cm x 20.5 cm

33 cm x 23 cm x 21 cm

Growth surface (device)

4,000 cm2

6,360 cm2

8,216 cm2

Max. devices / shelf

6

2

2

Max. devices / incubator

12

4

4

Growth surface (incubator load)

12 x 4,000 = 48,000 cm2

4 x 6,360 = 25,440 cm2

4 x 8,216 = 32,864 cm2

Utilisation

100 %

53 %

68.47 %

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